Medicine Recommendations

LSCMMG

Green

BwD

Green

Green

Green

Green

Green

Green

Pending

Green

Macrogol

Date Posted: 01 - Nov - 2016

BNF chapter: Gastro-intestinal system

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Constipation in adults

Green

Green

Green

Green

Green

Green

Green

Pending

Green

Macrogol (Laxido Paediatric ®)

Date Posted: 01 - Nov - 2016

BNF chapter: Gastro-intestinal system

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Constipation in children

Amber 2

Amber 2

Amber 2

Amber 2

Amber 2

Amber 2

Amber 2

Amber 2

Amber 2

Mercaptopurine

Date Posted: 01 - May - 2013

BNF chapter: Gastro-intestinal system

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Ulcerative colitis and Crohn's ONLY; only for inflammatory bowel diseases when patients are unable to tolerate azathioprine.

**Please note - For Blackpool, Fylde & Wyre CCGs DMARD Shared Care Guidelines please use the versions available on the CCG website

Amber 0

Amber 0

Amber 0

Amber 0

Amber 0

Amber 0

Amber 0

Amber 0

Pending

Mesalazine

Date Posted: 01 - Oct - 2014

BNF chapter: Gastro-intestinal system

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Ulcerative colitis

Amber 2

Red

Amber 2

Amber 2

Red

Amber 2

Amber 2

Amber 2

Pending

Methotrexate Subcutaneous Injection Pen

Date Posted: 01 - Oct - 2014

BNF chapter: Gastro-intestinal system

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Crohn's Disease

Black

Black

Black

Black

Black

Black

Black

Black

Black

Methylnaltrexone

Date Posted: 01 - May - 2013

BNF chapter: Gastro-intestinal system

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Opioid induced bowel dysfunction in palliative care (NICE TA 277 terminated)

NICE is unable to recommend the use in the NHS because no evidence submission was received from the manufacturer of the technology

NICE TA277 - Methylnaltrexone for treating opioid-induced bowel dysfunction in people with advanced illness receiving palliative care (terminated appraisal)

Red

Red

Red

Red

Red

Red

Red

Red

Red

Mirikizumab

Date Posted: 11 - Jan - 2024

BNF chapter: Gastro-intestinal system

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Moderately to severely active ulcerative colitis (NICE TA925)

NICE TA925 - Mirikizumab for treating moderately to severely active ulcerative colitis

Green

Green

Green

Green

Green

Green

Green

Green

Green

Naldemedine

Date Posted: 11 - Mar - 2021

BNF chapter: Gastro-intestinal system

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NICE TA651 - For treating opioid-induced constipation

Palliative Use Only

LSCMMG

Green (R)(Restricted)

BwD

Green (R)(Restricted)

BP

Green (R)(Restricted)

CSR

Green (R)(Restricted)

EL

Green (R)(Restricted)

FW

Green (R)(Restricted)

GP

Green (R)(Restricted)

MB

Green (R)(Restricted)

WL

Green (R)(Restricted)

Naloxegol

Date Posted: 06 - Apr - 2022

BNF chapter: Gastro-intestinal system

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Opioid-induced constipation

Green

Green

Green

Green

Green

Green

Green

Green

Green

Naloxegol

Date Posted: 01 - Sep - 2015

BNF chapter: Gastro-intestinal system

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Opioid-induced constipation (NICE TA345)

NICE TA 345 - Naloxegol for treating opioid‑induced constipation

Palliative Use Only

LSCMMG

Green (R)(Restricted)

BwD

Green (R)(Restricted)

BP

Green (R)(Restricted)

CSR

Green (R)(Restricted)

EL

Green (R)(Restricted)

FW

Green (R)(Restricted)

GP

Green (R)(Restricted)

MB

Green (R)(Restricted)

WL

Green (R)(Restricted)

Octreotide

Date Posted: 24 - Mar - 2022

BNF chapter: Gastro-intestinal system

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Bowel obstruction - GI secretions associated with bowel obstruction.

Palliative Use Only

LSCMMG

Green (R)(Restricted)

BwD

Green (R)(Restricted)

BP

Green (R)(Restricted)

CSR

Green (R)(Restricted)

EL

Green (R)(Restricted)

FW

Green (R)(Restricted)

GP

Green (R)(Restricted)

MB

Green (R)(Restricted)

WL

Green (R)(Restricted)

Ondansetron

Date Posted: 24 - Mar - 2022

BNF chapter: Gastro-intestinal system

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Bowel obstruction - nausea and vomiting associated with bowel obstruction

Red

Red

Red

Red

Red

Red

Red

Red

Red

Ozanimod

Date Posted: 14 - Nov - 2022

BNF chapter: Gastro-intestinal system

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Treating moderately to severely active ulcerative colitis - NICE TA828

NICE TA828 - Ozanimod for treating moderately to severely active ulcerative colitis

Amber 0

Pending

Amber 0

Amber 0

Pending

Amber 0

Amber 0

Amber 0

Amber 0

Prucalopride

Date Posted: 01 - Nov - 2016

BNF chapter: Gastro-intestinal system

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Treatment of chronic constipation in women (NICE TA211) and Use in men: Prucalopride for the treatment of chronic constipation in men (LSCMMG recommendation)

NICE TA211 - Prucalopride for the treatment of chronic constipation in women

Red

Red

Red

Red

Red

Red

Red

Red

Red

Risankizumab

Date Posted: 16 - Jun - 2023

BNF chapter: Gastro-intestinal system

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Previously treated moderately to severely active Crohn's disease (NICE TA888)

NICE TA888 - Risankizumab for previously treated moderately to severely active Crohn's disease

Green

Green

Green

Green

Green

Green

Green

Pending

Green

Senna

Date Posted: 01 - Nov - 2016

BNF chapter: Gastro-intestinal system

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Constipation in children

Palliative Use Only

LSCMMG

Green (R)(Restricted)

BwD

Green (R)(Restricted)

BP

Green (R)(Restricted)

CSR

Green (R)(Restricted)

EL

Green (R)(Restricted)

FW

Green (R)(Restricted)

GP

Green (R)(Restricted)

MB

Green (R)(Restricted)

WL

Green (R)(Restricted)

Senna

Date Posted: 31 - Mar - 2022

BNF chapter: Gastro-intestinal system

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Constipation

Opioid-induced constipation

Red

Red

Red

Red

Red

Red

Red

Red

Red

Sucralfate (enema)

Date Posted: 30 - Apr - 2024

BNF chapter: Gastro-intestinal system

Radiation proctitis

Amber 0

Amber 0

Amber 0

Amber 0

Amber 0

Amber 0

Amber 0

Amber 0

Amber 0

Sucralfate (suspension and tablets)

Date Posted: 30 - Apr - 2024

BNF chapter: Gastro-intestinal system

Bile acid gastritis

Amber 2

Amber 2

Amber 2

Amber 2

Amber 2

Amber 2

Amber 2

Amber 2

Pending

Sulfasalazine

Date Posted: 01 - Oct - 2014

BNF chapter: Gastro-intestinal system

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Breadcrumb

Medicine Recommendations

Constipation in adults

Constipation in children

Ulcerative colitis and Crohn's ONLY; only for inflammatory bowel diseases when patients are unable to tolerate azathioprine.

**Please note - For Blackpool, Fylde & Wyre CCGs DMARD Shared Care Guidelines please use the versions available on the CCG website

Ulcerative colitis

Crohn's Disease

Opioid induced bowel dysfunction in palliative care (NICE TA 277 terminated)

NICE is unable to recommend the use in the NHS because no evidence submission was received from the manufacturer of the technology

Opioid-induced constipation (NICE TA345)

Treatment of chronic constipation in women (NICE TA211) and Use in men: Prucalopride for the treatment of chronic constipation in men (LSCMMG recommendation)

Constipation in children

Crohn's disease